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Gluretor 0.5mg Tablet 1 Strip

Generic: Repaglinide

Type: Tablet

Pack Size: 10 Pcs

Gluretor belongs to the meglitinide class of oral hypoglycemic agents, designed for the management of Type 2 diabetes.

  • It functions by stimulating the pancreas to release insulin into the bloodstream.
  • It has a rapid onset of action and a short duration, making it effective for controlling post-meal glucose spikes.

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✅ Description:

Pack Image of Gluretor 0.5 mg Tablet
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✔️ Indications: Gluretor 0.5

Gluretor is prescribed as an adjunct to diet and exercise for lowering blood glucose levels in patients with Type 2 diabetes mellitus (NIDDM) when dietary and lifestyle modifications alone fail to achieve adequate glycemic control.

  • It is also indicated for combination therapy with Metformin in cases where either Gluretor or Metformin alone is insufficient to control blood glucose levels.

Note: This medication should only be taken under the guidance of a registered physician.

✔️ Mechanism of Action: Gluretor 0.5
  • Gluretor (Repaglinide) binds to specific receptors on pancreatic beta cells, leading to the closure of ATP-dependent potassium (K+) channels.
  • This causes depolarization of the cell membrane, allowing calcium (Ca++) influx into the cells.
  • The increased intracellular calcium triggers insulin secretion, thereby reducing blood glucose levels.
✔️ Side Effects of Gluretor 0.5
  • Common side effects:
    • Hypoglycemia (low blood sugar), with symptoms like dizziness, sweating, confusion, and weakness.
    • Gastrointestinal issues, including diarrhea, constipation, nausea, and vomiting.
    • Upper respiratory tract infections.
  • Rare hypersensitivity reactions:
    • Skin rashes, urticaria (hives).
✔️ Dosage & Administration of Gluretor 0.5
  • For newly diagnosed patients or those with HbA1c <8%:
    • Start with 0.5 mg before each meal.
  • For patients previously on glucose-lowering drugs with HbA1c >8%:
    • Initiate with 1 or 2 mg before each meal.
  • Administration Guidelines:
    • Gluretor should be taken immediately or up to 30 minutes before meals.
    • The dosage can be adjusted based on response at 1- to 2-week intervals.
    • The maximum single dose is 4 mg, and the daily dose should not exceed 16 mg.

Note: This medication should be taken as per a physician’s recommendation.

✔️ Drug Interactions
  • Drugs that increase Gluretor levels (risk of prolonged action):
    • Inhibitors of cytochrome P450 enzymes (e.g., azole antifungals, macrolides) can reduce Gluretor clearance, leading to longer-lasting effects.
  • Drugs that accelerate Gluretor metabolism (shortening its effect):
    • P450 enzyme inducers (e.g., Rifampin, Phenobarbital, Carbamazepine, Troglitazone) speed up its breakdown, potentially reducing effectiveness.
  • Drugs with no significant effect on Gluretor:
    • Cimetidine does not impact its absorption or clearance.
    • Gluretor does not significantly interact with Digoxin, Theophylline, or Warfarin.
  • Highly protein-bound drugs (e.g., NSAIDs):
    • These may increase unbound Gluretor levels, enhancing its glucose-lowering effect and potentially increasing hypoglycemia risk.
  • Medications that may increase the risk of hypoglycemia:
    • Salicylates, sulfonamides, chloramphenicol, coumarins, probenecid, MAO inhibitors, and adrenergic blockers can potentiate Gluretor’s hypoglycemic effect, increasing the risk of dangerously low blood sugar levels.
✔️ Overdose Effects
  • High doses (up to 80 mg) have been tolerated with minimal adverse effects beyond blood sugar reduction.
  • Hypoglycemia is unlikely if food is consumed in high doses.
  • Severe hypoglycemic episodes (coma, seizures, neurological impairment) are rare but require immediate medical intervention.
✔️ Pregnancy & Lactation
  • Pregnancy:
    • Safety in pregnant women has not been established. It should only be used if the benefits outweigh the risks.
  • Lactation:
    • It is unknown whether Repaglinide is excreted in human milk.
    • Due to the potential for adverse effects in infants, a decision must be made whether to discontinue breastfeeding or discontinue the drug, depending on its importance to the mother.
✔️ Gluretor (Repaglinide) should not be used in patients with:
  • Diabetic ketoacidosis, with or without coma.
  • Type 1 diabetes mellitus (as it requires insulin therapy).
  • Known hypersensitivity to Repaglinide or its inactive components.
✔️ Precautions & Warnings
  • Substituting Insulin During Illness or Surgery:
    • In cases of severe illness, trauma, infection, or surgery, insulin may be required instead of Gluretor.
  • Hypoglycemia Risk:
    • Like all oral glucose-lowering agents, Gluretor can cause hypoglycemia.
    • To minimize this risk, it should be taken with meals.
  • Use in Patients with Hepatic Impairment:
    • Since Repaglinide is metabolized in the liver, caution is advised in patients with liver dysfunction.
✔️ Storage Conditions
  • Store at a temperature below 30°C, away from light and moisture.
  • Keep out of reach of children.
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Check our pricing section for Gluretor 0.5mg Tablet 1 Strip price in Bangladesh. After Submitting Order, You may receive phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.

📦Pricing Information, Availability:
Product Availability & Pricing Notice Please note that pricing, availability, and service offerings are subject to change due to: Market fluctuations, Manufacturer or supplier adjustments, Product discontinuation or temporary unavailability, Advertising errors. All orders depend on stock availability and staff resources. If services are provided on a time-and-materials basis, any shared estimates are for planning purposes only.

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